Disfigured by smallpox, Cherokee men resort to suicide:

"A great many killed themselves; for being naturally proud, they are always peeping into their looking glasses, and are never genteelly drest, according to their mode, without carrying one hung over their shoulders: by which means, seeing themselves disfigured, with hope of regaining their former beauty, some shot themselves, others cut their throats, some stabbed themselves with knives, and others with sharp-point canes; many threw themselves with sullen madness into the fire, and there slowly expired, as if they had been utterly divested of the native power of feeling pain."

from The History of the American Indians (1775) by James Adair